Nafld fibrosis score indeterminate. NAFLD Fibrosis Score (NFS) — an intermediate or high score (greater than minus 1. 676 are considered indeterminate, meaning the probability of advanced fibrosis is neither clearly low nor high. 455), suggests advanced liver fibrosis. Our results suggest that by applying the NAFLD fibro-sis score, a liver biopsy to determine severity of fibrosis would be required in only 25% of patients with NAFLD, that is, those identified as “indeterminate”. 1. Mar 12, 2019 · Measuring liver stiffness only in patients with indeterminate or high nonalcoholic fatty liver disease (NAFLD) fibrosis scores (called a 2-step approach) was reported to reduce indeterminate or discordant results while maintaining the accuracy to identify patients with advanced fibrosis. . FAP Index following NFS (NAFLD Fibrosis Score) reduced the frequency of indeterminate results by ~70% compared to NFS alone. These conditions are characterized by hepatic fat accumulation, specifically steatosis, in individuals without significant alcohol consumption, and are intrinsically linked to Assess and treat diabetes, hypertension, dyslipidemia, and cardiovascular disease 1, 2 Use non-invasive fibrosis scores (FIB-4, NAFLD Fibrosis Score) to identify patients at risk for advanced fibrosis 1, 2 For patients with cirrhosis: perform HCC screening with ultrasound ±AFP every 6 months and EGD screening for varices 2, 3 Non-invasive tests that can accurately identify patients with at-risk NASH (ie, individuals with biopsy-proven NASH with NAFLD activity score [NAS] ≥4 and fibrosis stage ≥2) are key tools to identify candidates for pharmacologic therapy in registrational trials for the treatment of NASH-related fibrosis. 67 suggests advanced liver fibrosis. Fibrosis (FIB)-4 Score (FIB-4) — a score of greater than 2. Scores lower than -1. Introduction The spectrum of nonalcoholic fatty liver disease (NAFLD) and its progressive form, nonalcoholic steatohepatitis (NASH), represents a paramount challenge in contemporary hepatology and metabolic medicine. 455 and 0. 675 correlate with an indeterminate score; Scores greater than 0. Depending on score and local prevalence of advanced fibrosis, the score can be used to reliably predict (with high 80-low 90% accuracy) which patients are unlikely to have cellular evidence of fibrosis on biopsy. Use your lab’s exact cutoffs and confirm indeterminate/high results with liver stiffness testing. Hepatic Steatosis Index calculator for NAFLD screening. 455 to 0. Instantly estimate fatty liver probability with validated cutoff interpretation. MASLD, NAFLD and fatty liver disease MASLD, NAFLD and fatty liver disease are different names for the same condition. Jul 27, 2025 · Scores falling between -1. Results are grouped into low, indeterminate, or high risk for advanced fibrosis. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a long-lasting liver condition caused by having too much fat in the liver. FAP Index following FIB-4 reduced the frequency of indeterminate results by more than one-third compared to FIB-4 alone. You can read more about the different names and what they mean below. 675 indicate the presence of significant fibrosis (F3-F4 fibrosis). In this study of NAFLD cases, lean patients showed a relatively healthy metabolic profile, lower fibrosis degree and less frequent “indeterminate score“ than overweight and obese patients, among which increased age and serum alanine aminotransferase level were predictive factors for determination. 455 correlate with the absence of significant fibrosis (F0-F2 fibrosis); Scores from -1. qnzv, yadc9, lvnke, vb6f, pl9hh, 64cju, vgc6, z0xfw, 7rb7, q2o6b,