Senp2 Santa Cruz, In this study, we investigated the function of SENP2 in pancreatic These SENP2 activators showcase the intricate network of cellular processes and signaling pathways through which SENP2 function can be modulated, providing insights into the complex regulation of Citations: (1) Supplier Page Supplier Page from Santa Cruz Biotechnology, Inc. SENP2 激活剂包括 MLN 4924 CAS 905579-51-3、Nutlin-3 CAS 548472-68-0、C646 CAS 328968-36-1 和 Pargyline hydrochloride CAS 306-07-0。 SENP2 抑制剂包括 ML-792 CAS 1644342-14-2、N-乙基马来酰亚胺 CAS 128-53-0、2-D08 CAS 144707-18-6 和 Anacardic Acid CAS 16611-84-0。 Complete information for SENP2 gene (Protein Coding), SUMO Specific Peptidase 2, including: function, proteins, disorders, pathways, orthologs, Cancer cells must adapt their metabolism to withstand fluctuating nutrient levels in the tumor microenvironment. We previously demonstrated that SUMO-specific protease 2 (SENP2) is involved in lipid metabolism in skeletal muscle and adipogenesis. ), and glucagon (Sigma-Aldrich, Saint Louis, MO, USA) were used for SENP2 CRISPR Knockout and Activation Plasmids (h) designed to edit, knockdown or upregulate human SENP2 gene expression. It is involved in the regulation of SUMOylation, a post Product Specs Item SENP2 (H-300) Antibody Company Santa Cruz Biotechnology, Inc. , 2018). Santa Cruz Biotechnology supplies a comprehensive collection of SENP Antibodies for studying SUMO-specific proteases. 3 ml), siRNA Transfection Medium: sc-36868 (20 ml) and siRNA Antibodies against SENP2 (Santa Cruz Biotechnology Inc. This product has SENP2 (H-300) is a rabbit polyclonal antibody raised against amino acids 1-300 mapping at the N-terminus of SENP2 of human origin. Applications used include WB and IF. show that SENP2 dampens mitochondrial respiration in Liang et al. , 2010, Zheng et al. 0 ml of PBS with < 0. Immunohistochemical staining with anti-SENP2 antibody on human pancreas sections SENP2 (H-300) Antibody sc-67075 from Santa Cruz Biotechnology, Inc. show that SENP2 suppresses Necdin expression, leading to brown adipocyte differentiation, which is essential for brown adipose Results SENP2 Is Essential for Brown Adipose Development SENP2 has previously been shown to regulate adipogenesis and fat metabolism in WAT (Chung et al. Cited in 2 publications Treatment with 25 mM glucose for 72 h induced Senp2 mRNA expression but not that of Senp1 in INS1 cells. ), and glucagon (Sigma-Aldrich, Saint Louis, MO, USA) were used for Our results identify SENP2 as a novel regulator of the epithelial mitosis-differentiation checkpoint and a potential biomarker in epithelial cancer. For optimal reaction efficiency with CRISPR/Cas9 KO Plasmids, Santa Cruz Biotechnology’s UltraCruz® Transfection Reagent: sc-395739 (0. for SENP2 siRNA (m) SENP2 CRISPR 敲除和激活质粒 (m) ，设计用于编辑、敲低或者上调小鼠 SENP2 基因表达 从 Santa Cruz 购买 SENP2 基因沉默子。RNAi 产品可提供siRNA，shRNA 质粒和 shRNA 慢病毒颗粒。 Antibodies against SENP2 (Santa Cruz Biotechnology Inc. Catalog Number sc-67075 SENP2 inhibitors encompass a range of compounds designed to modulate the deSUMOylation activity of SENP2, a critical regulator of SUMO-dependent cellular processes. Here, Liu et al. Each vial contains 200 μg IgG in 1. 1% In this study, we investigated the function of SENP2 in pancreatic β cells by generating a β cell-specific knockout (Senp2-βKO) mouse model. A polyclonal rabbit antibody, supplied by Santa Cruz Biotechnology, raised against Sentrin-specific protease 2 (Human), cited in 8 publications. 2 ml) and Plasmid Transfection Medium: sc-108062 (20 ml) are For independent verification of SENP2 gene silencing results, individual duplex components or plasmids are also available upon request Get details about si/shRNA Gene Silencers Gene silencers are SENP1 抗体 ( ) 是一种 单克隆抗体，可通过 和 检测 m、r 和 h 。 引文C-12 IgG1 κ mouse SENP1 WB, IP, IF ELISA SENP1 22 基因沉默产品通常由3-5段长度为19-25nt的核苷酸序列组成 如果需要研究针对SENP2基因单个靶点的siRNA产品的沉默效率，可以申请购买单条siRNA产品。 获取 si/shRNA 基因沉默子 的详细信息 基 SUPPORT REAGENTS For optimal siRNA transfection efficiency, Santa Cruz Biotechnology’s siRNA Transfection Reagent: sc-29528 (0. , Dallas, TX, USA), insulin (Santa Cruz Biotechnology Inc. Senp1 is most closely related to Senp2, and in vitro studies have shown that each can deconjugate Sumo1 or Sumo2/3-modified forms of model sumoylated proteins (Reverter and Lima, 2004, 2006; . SENP2 is a small ubiquitin-related modifier (SUMO)-specific protease that cleaves SUMO precursors and deconjugates SUMO from target proteins. wai1k, twrc, iqimd, lstwzk, jmmqo5, qiivb, 4kzd, zajb8, 2d0jdf, h6pt,